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CLINIZONE

Guidelines

Choosing Antihypertensives

Age

<55 Years

>55 years or Afro-Caribbean (any age)

lisinopril 10-20mg OD(A) or ramipril 2.5-10mg OD(A) or losartan 25-100mg OD(A)
amlodipine 5-10mg OK(C) or indapamide 2.5mg OD(C)

<55 Years

>55 years or Afro-Caribbean (any age)

lisinopril 10-20mg OD(A) or ramipril 2.5-10mg OD(A) or losartan 25-100mg OD(A)
amlodipine 5-10mg OK(C) or indapamide 2.5mg OD(C)
Target BP not achieved.
Ensure at optimal or
best tolerated doses.
Combine
A and C or D
Target BP not achieved.
Ensure at optimal or
best tolerated doses.
Combine
A and C and D
Target BP not achieved.
Ensure at optimal or
best tolerated doses.
Add Spironolactone 25mg OD
(monitor renal function closely, avoid if eGFR <30ml/min or baseline K>4.5
Target BP not achieved.
Ensure at optimal or
best tolerated doses.
Doxazosin 2-16mg OD (do not use the MR preparation)
or
Bisoprolol 2.5-10mg OD